Note: Since the time I compiled this info, I discovered that Green Med Info did a excellent job of compiling scientific studies. I encourage you to click on this link for over 300 pages of peer-reviewed scientific abstracts culled directly from the National Library of Medicine’s pubmed.gov bibliographic database on the wide-ranging adverse health effects linked to vaccines in the today’s schedule (over 200 distinct adverse effects, including death), as well as numerous studies related to vaccine contamination, and vaccine failure in highly vaccine compliant populations (more info about this here).
In addition, this document (“Vaccine Peer Review”) provides over 1,000 peer-reviewed scientific abstracts about vaccines.
Global Vaccine Institute also lists several scientific studies that document hazards associated with vaccines.
Combining Childhood Vaccines in one Visit is not Safe
Infants who receive several vaccines concurrently are significantly more likely to be hospitalized or die when compared with infants who receive fewer vaccines simultaneously.
Miller, N.Z. 2016. Combining Childhood Vaccines in One Visit is Not Safe. Journal of American Physicians and Surgeons 21(2):47-49.
Read article here.
Excessive vaccinations can lead to neurological damage in the brains of developing children
**This paper is the one to read, if you only want to read one.**
Blaylock, R.L. 2008. The danger of excessive vaccination during brain development: the case for a link to Autism Spectrum Disorders (ASD). Medical Vertias 5(2008):1727-1741. (You need Word to open the link above. If you don’t have Word, you can also read it on Dr. Mercola’s website here).
Blaylock, R.L. 2004. ”Chronic Microglial Activation and Excitotoxicity Secondary to Excessive Immune Stimulation: Possible Factors in GulfWar Syndrome and Autism”. Journal of American Physicians and Surgeons 9(2):Summer 2004.
“Theoretical aspects of autism: causes — a review” states that “Documented causes of autism include genetic mutations and/or deletions, viral infections, and encephalitis [brain damage] following vaccination [emphasis added]. Therefore, autism is the result of genetic defects and/or inflammation of the brain.” Read the abstract to Ratajczak’s paper here and a CBS news article about the paper here.
Do aluminum vaccine adjuvants contribute to the rising prevalance of autism?
J Inorg Biochem. 2011 Nov;105(11):1489-99. doi: 10.1016/j.jinorgbio.2011.08.008. Epub 2011 Aug 23.
“Our results show that: (i) children from countries with the highest ASD prevalence appear to have the highest exposure to Al from vaccines; (ii) the increase in exposure to Al adjuvants significantly correlates with the increase in ASD prevalence in the United States observed over the last two decades (Pearson r=0.92, p<0.0001); and (iii) a significant correlation exists between the amounts of Al administered to preschool children and the current prevalence of ASD in seven Western countries, particularly at 3-4 months of age (Pearson r=0.89-0.94, p=0.0018-0.0248). The application of the Hill’s criteria to these data indicates that the correlation between Al in vaccines and ASD may be causal.”
Fiejka, M. and J. Aleksandrowicz. 1993. Aluminum as an adjuvant in vaccines and post-vaccines reactions. Rocz Panstw Zakl Hig. 1993;44(1):73-80.
Infant mortality rates regressed against number of vaccine doses routinely given: Is there a biochemical or synergistic toxicity? Hum Exp Toxicol. 2011 Sep; 30(9): 1420–1428. Abstract here.
The infant mortality rate (IMR) is one of the most important indicators of the socio-economic well-being and public health conditions of a country. The US childhood immunization schedule specifies 26 vaccine doses for infants aged less than 1 year—the most in the world—yet 33 nations have lower IMRs. Using linear regression, the immunization schedules of these 34 nations were examined and a correlation coefficient of r = 0.70 (p < 0.0001) was found between IMRs and the number of vaccine doses routinely given to infants.
In summary, nations that have a larger number of vaccinations have greater infant mortality rates).
Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010. Hum Exp Toxicol. 2012 Oct; 31(10): 1012–1021. Abstract here.
In this study, the Vaccine Adverse Event Reporting System (VAERS) database, 1990–2010, was investigated; cases that specified either hospitalization or death were identified among 38,801 reports of infants. Our findings show a positive correlation between the number of vaccine doses administered and the percentage of hospitalizations and deaths.
Summary: As the number of vaccine doses increases, the percentage of hospitalization and deaths increase.
In a study recently published in the journal Human & Experimental Toxicology, researchers evaluated the overall number of hospitalizations and deaths associated with vaccines administered between 1990 and 2010, and compared this data to the number of vaccines given at one time to individual children. Hospitalizations and deaths resulting from one vaccine dose were compared to those of two vaccine doses, in other words, and the same all the way up to eight vaccine doses. Researchers also evaluated overall hospitalization and death rates associated with getting one to four combined vaccine doses, five to eight combined vaccine doses, and one to eight combined vaccine doses.
Upon analysis, the team found that the more vaccines a child receives during a single doctor visit, the more likely he or she is to suffer a severe reaction or even die.
A layman’s article about this paper here.
Campo, D.A. 1967. Physiological changes of the vaccinated organism: a basis for the interpretation of the clinical complications due to prophylactic vaccines. Prog Immunobiol Stand. 3:280-4.
Orntoft et al. 2013. Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. Scand J Clin Lab Invest. 2013 May 13.
In 2013, Dr Orntoft published research detailing the genetic network changes in white blood cells before, and six weeks after, DTP booster vaccination in 8 different girls. Here is a list of the top networks altered after the vaccine.
Read abstract here.
Lahdenpera et al. 2008. Kinetics of asthma- and allergy-associated immune response gene expression in peripheral blood mononuclear cells from vaccinated infants after in vitro re-stimulation with vaccine antigen. Vaccine 26(14):1725-30.
Read abstract here.
Read Dr. Suzanne Humphries’ article about this study here.
“A review of 50 studies that included more than 70,000 adults found that 100 people needed to be vaccinated to avoid one case of flu. That means the vaccine failed 99 percent who took it — they received no benefit at preventing the flu.” – Source
Exposure to hemophilus influenza B (HiB) immunization is associated with an increased risk of insulin dependent diabetes.
Classen, J.B. and D.C. Classen. 2003. Clustering of cases of insulin dependent diabetes (IDDM) occuring thre years after hemophilus influenza B (Hib) immunization support causal relationship between immunization and IDDM. Autoimmunity. May 2003; 36(3):123.
Jefferson, T. 2006. Influenza vaccination: policy versus evidence. British Medical Journal 2006;333:912.
Phone survey showed that vaccinated boys were more likely to have a neurological disorder, ADHD and autism than unvaccinated boys (non-peer-reviewed study).
“All vaccinated boys, compared to unvaccinated boys:- Vaccinated boys were 155% more likely to have a neurological disorder (RR 2.55) – Vaccinated boys were 224% more likely to have ADHD (RR 3.24) – Vaccinated boys were 61% more likely to have autism (RR 1.61) Older vaccinated boys, ages 11-17 (about half the boys surveyed), compared to older unvaccinated boys: – Vaccinated boys were 158% more likely to have a neurological disorder (RR 2.58) – Vaccinated boys were 317% more likely to have ADHD (RR 4.17) – Vaccinated boys were 112% more likely to have autism (RR 2.12) (Note: older children may be a more reliable indicator because many children are not diagnosed until they are 6-8 years old, and we captured data beginning at age 4.)”
Adults who have received Hepatitis B vaccinations are statistically associated with neurological changes, gastrointestinal disease, multiple sclerosis and arthritis.
Geier, D.A., M.R. Geier. 2002. Chronic adverse reactions associated with Hepatitis B vaccination. Annals of Pharmacotherapy 36(12):1970-1971.
Children who receive the entire 3-shot series of Hepatitis B Vaccine have a 9x higher rate of developmental disabilities than unvaccinated children.
Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years
Toxicological and Environmental Chemistry, September 2008, Carolyn Gallagher and Melody Goodman.
Primates receiving the Hepatitis B vaccine experienced developmental delays compared to unvaccinated primates.
Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight
Neurotoxicology, October 2009, Laura Hewitson, Lisa A. Houser, Carol Stott, et. al.
A delay in the timing of DPT vaccine lowers the rate of asthma.
Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma
Journal of Allergy and Clinical Immunology, 2008 Kara L. McDonald, MS, Shamima I. Huq, BS, Lisa M. Lix, PhD, Allan B. Becker, MD, FRCPC, and Anita L. Kozyrskyj, PhD
Read more about this here.
There is a causal relationship between measles vaccines and acute encephalopathy and permanent brain injury or death.
Acute encephalopathy followed by permanent brain injury or death associated with further attenuated measles vaccines: a review of claims submitted to the National Vaccine Injury Compensation Program. PEDIATRICS Vol. 101 No. 3 March 1998, pp. 383-387
R.E. Weibel, V. Caserta, D.E. Benor and G. Evans.
Children with neurological disorders are often suffering from severe gastrointestinal distress and inflammation. A trigger of this inflammation and the resultant behaviors is the MMR vaccine.
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Lancet 1998 Feb 28 Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, [University Department of Medicine, Royal Free Hospital and School of Medicine, London, UK]
The Significance of Ileo-Colonic Lymphoid Nodular Hyperplasia in Children With Autism Spectrum Disorder.
European Journal of Gastroenterology & Hepatology, August 2005. Andrew J. Wakefield, MD [Royal Free & University College Medical School, London].
Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism
Digestive Diseases and Sciences, 2000 Hisashi Kawashima, Takayuki Mori, Yasuyo Kashiwagi, Kouji Takekuma
- This study shows that the measles in the bowels of autistic children is from the MMR vaccine.
Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.
Neuropsychobiology, 2005. Harumi Jyonouchi, MD [New Jersey Medical School].
- This study examines the link between autistic behaviors and gastrointestinal disorders and notes a possible link “between GI and behavioral symptoms mediated by innate immune abnormalities.”11
Link between MMR vaccination and autism
Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism
Vijendra K. Singh, Sheren X. Lin, Elizabeth Newell, Courtney Nelson. 2002. Abnormal Measles-Mumps-Rubella Antibodies and CNS Autoimmunity in Children with Autism. Journal of Biomedical Science 2002(9):359-364.
- The team led by Dr Vijendra Singh analysed blood samples from 125 autistic children and 92 children who did not have the developmental disorder.
- The researchers found a “significant increase” in the level of MMR antibodies in the autistic children.
- Part of the measles component of the vaccine caused an unusual anti-measles response in 75 of the autistic children, but not in the normal children.
- More than 90% of the autistic samples, which showed an immune response to MMR, were also positive for antibodies thought to be involved in autism.
- These antibodies attack the brain by targeting the basic building blocks of myelin, the insulating sheath that covers nerve fibres.
- Dr Singh has suggested that this autoimmune response may be the root cause of autism.
Geier, D.A. and M.R. Geier. 2004. A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Med Sci Monit, 2004; 10(3): PI33-39
- It was determined that there was a close correlation between mercury doses from thimerosal-containing childhood vaccines and the prevalence of autism from the late 1980s through the mid-1990s.
- In contrast, there was a potential correlation between the number of primary pediatric measles-containing vaccines administered and the prevalence of autism during the 1980s.
- In addition, it was found that there were statistically significant odds ratios for the development of autism following increasing doses of mercury from thimerosal-containing vaccines (birth cohorts: 1985 and 1990-1995) in comparison to a baseline measurement (birth cohort: 1984).
- The contribution of thimerosal from childhood vaccines (>50% effect) was greater than MMR vaccine on the prevalence of autism observed in this study.
Buttram, H.E. 1998. Measles-Mumps-Rubella (MMR) vaccine as a potential cause of enchephalitis (brain inflammation) in children. Townsend Letter for Doctors.
- Read more about this article here.
Yazbak, F.E., K.L. Lang-Radosh. 2001. Adverse Outcomes Associated with Postpartum Rubella or MMR Vaccines. Medical Sentinel 2001;6(3):95-99, 108.
One preservative used in vaccines, Thimerosal (mercury), enters the bloodstream of the child and ends up in the brain after being administered.
Iatrogenic Exposure to Mercury After Hepatitis B Vaccination in Preterm Infants.
Journal of Pediatrics, May 2000. Gregory V. Stajich, PharmD [Mercer University].
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal.
Environmental Health Perspectives, Aug 2005. Thomas Burbacher, PhD [University of Washington].
The preservatives in vaccines, most notably Thimerosal (mercury) and aluminum, are highly toxic and damaging to the nervous system and immune system of a developing child, and reactions to these toxins may vary greatly by child.
Thimerosal Neurotoxicity is Associated with Glutathione Depletion: Protection with Glutathione Precursors.
Neurotoxicology, Jan 2005. S. Jill James, PhD [University of Arkansas].
- See this link for 8 other scientific studies on this topic.
The symptoms of autism and the symptoms of mercury poisoning appear to be very similar.
Autism: A Novel Form of Mercury Poisoning.
Medical Hypothesis, 2001. Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Teresa Binstock, PhD.
The increase in pertussis incidence was higher among vaccinated than among unvaccinated persons of all ages.
Re-emergence of pertussis among highly vaccinated population in the Netherlands.
“In 2005, researchers at the University of Illinois at Chicago conducted a study relating to asthma, hay fever, eczema and vaccination status. Working with the National Vaccine Information Center membership, researchers anonymously identified 515 never vaccinated, 423 partially vaccinated and 239 completely vaccinated children. They concluded that parents of unvaccinated children were 11 times less likely to report asthma for children with no family history of the disease and no exposure to antibiotics in infancy. Parents of unvaccinated children were 10 times less likely to report hay fever among children with no family history of hay fever. Eczema was also reported significantly less in unvaccinated children.
Unvaccinated children also appear to have a lower incidence of autism, according to a 2005 investigation by UPI reporter Dan Olmstead, who looked at an unvaccinated Amish population in Lancaster, Pennsylvania. If the CDC’s calculation that one in 166 children [was] autistic [was] correct, Olmstead calculated that at least 100 children in Lancaster should have autism. He found only three: a girl adopted from China, an Amish child who had been vaccinated and developed autism shortly afterwards, and another child whose vaccination status was unclear.”
— Barbara Loe Fisher, National Vaccine Information Center (NVIC)
Note: On March 27, 2014, the CDC released a report estimating that 1 in 68 children in the US has an autism spectrum disorder (ASD), a 30% increase from 1 in 88 two years previous. In 2013, the CDC had released another report estimating that 1 in 50 children between the ages of 6 and 17 had been diagnosed with an ASD. In the 1980s, ASD prevelance in the US was 1 in 10,000.
Vaccination and Allergy citations
Fries, J H, Coleman, M, “Anaphylactoid Allergic Reaction to Influenza and Poliomyelitis Vaccines”, Ann Allerg, Oct 1960; 18:1130-1137.
Bernard, JG, et al, “Vaccination Complications and Cutaneous Allergic Reactions in Young Adults”, Rey Corps Sante Armees, Feb 1962; 3:35-46.
Smith, RE, “Allergic Reactions to Immunization Materials In Children and Approach to Diagnosis”, Ann Allerg, Dec 1965; 23:600-603.
Erdmann, G, “Vaccination Allergy”, Muenchen Med Wachr, Jun 16, 1961; 103:1217-1219 & 103:1256-1259.
Kreinin, LS, et al, “On the Problem of the Allergizing Effect on the Respiratory Organs of Aerosol Vaccination and Revaccination against Typhoid and Tetanus”, Zh Mikrobiol, Aug 1968, 45:130-132.
Fedotova, AM, “The Pathogenesis of Manifestations of Non-specific Allergy During Vaccination, Pediatria, Jan 1967; 46:56-60.
D’iakova, R M, “Allergic Reaction in Children”, Pediat Akush Ginek, Jan-Feb 1966, 1:20-21. [Listed under Vaccines.]
Isacson, P et al, “Allergic Reactions Associated with Viral Vaccines”, Prog Med Virol, 1971, 13:239-270.
Kantchourine, AK, et al, “Role of Delayed Allergic Reactions in the Pathogenesis of Post-Vaccinal Typhoid Complications”, Rev Franc Allerg, Jan-Mar 1969, 9:19-24.
Bawa YS, Wahi PL, “Allergic Encephalomyelitis after Vaccination and Serum Therapy: Report of Ten Cases”, Indian J Med Sci, Apr 1961;15:290-297.
Nazareth, B, et al, “Systemic Allergic Reactions to Japanese Encephalitis Vaccines”, Vaccine, May 1994, 12(7):666.
Weisse, ME, et al, “Tetanus Toxoid Allergy”, JAMA, Nov 14, 1990, 264 (18):2448.
Mazurin, A V, et al, “Severe Allergic Reaction with Hemorrhagic Syndrome Following the Administration of DPT Vaccine”, Vop Okhr Materin Dets, Mar 1964, 9:87-89.
Ehrengut, W, “Vaccinal Allergy, Systemic Vaccinia and Ulcerous Vaccinia”, Presse Med, July 4, 1964, 72:1957-1958.
Vaccination and Anaphylaxis Citations:
Koval’skala Sia, “Anaphylactogenic Properties of ADT, PDT, and APDT Vaccines…”, Zh Mikrobiol, Jan 1969; 46:65-71.
Egorova, NB, “Anaphylactic Reaction And Anti-toxin Titre Following Aerosol and Subcutaneous Immunization Against Tetanus”, Zh Mikrobiol, Apr 1968, 45:63-68.
Ovens, H, “Anaphylaxis Due to Vaccination in the Office”, Can Med Assoc J, Feb 15, 1986, 134(4):369-370.
NA, “Anaphylaxis Due to Vaccination in the Office”, Can Med Assoc J, May 15, 1986, 134(10): 1109.
James, LP, Jr, et al, “Fatal Systemic Anaphylaxis in man”, NEJM, Mar 19, 1964; 270:597-603.
Wiseman, “Anaphylactoid Reaction to Tetanus Toxoid”, Ann Allerg, Nov 1982, 49(5):308.
Proctor, JW, et al, “Anaphylactoid Reaction to Intralesional BCG”, Lancet, Jul 15, 1978, 2(8081):162.
Kelleher, PC, et al, “Anaphylactoid Reaction After Typhoid Vaccination”, Am J Med, Dec 1990, 89(6):822-824.
Lear, J T, et al, “Anaphylaxis After Hepatitis B Vaccination”, Lancet, May 13, 1995, 345(8959): 1249.
Leung AK, “Anaphylaxis to DPT vaccine.” J R Soc Med 1985 Feb; 78(2):175.
Wilkins J, “Circulating immune complexes after DTP vaccination.”, J Pediatr 1987 Jul; 111(1):162.
Valovirta E, “Circulating immune complexes during immunotherapy in allergy to dog.” Allergy 1989 Feb; 44(2):123-131.
Bunnag C, Dhorranintra B, “A preliminary study of circulating immune complexes during allergen immuno-therapy in Thai patients.” Asian Pac J Allergy Immunol 1989 Jun; 7(1):15-21.
Spinozzi F, et al, “Circulating immune complexes and serum lysozyme levels in untreated Hodgkin’s disease. Their relationship to immune function.” J Clin Lab Immunol 1983 Oct; 12(2):87-92.
Vaccines and Immune Suppression citations:
Toraldo, R, et al, “Effect of Measles-Mumps-Rubella Vaccination on Polymorphonuclear Neutrophil Functions in Children”, Acta Paediatr, 1992 Nov; 81(11):887-890.
Munyer, et al, “Depressed Lymphocyte Function after Measles-Mumps-Rubella Vaccination”, JourInfection Disorder, vol 132, No 1, July 1975, p 75-80.
Oski and Naiman, “Effect of Live Measles Vaccine on the Platelet Count”, NEJM, Aug 18, 1966, p 352-356.
Reik, L Jr, “Disseminated Vasculomyelinopathy: An Immune Complex Disease”, Ann Neurol, Apr 1980, 7(4):291-296.
Wilkins and Wehrle, “Additional Evidence Against Measles Vaccine Administration to Infants Less than 12 months of Age: Altered Immune Response Following Active-Passive Immunization, Jour Ped, 1979, Vol 94, p 865-869.
Futton, A et al, “Vaccines May Cause Immune Suppression”, Vaccine, Jan 1999, 17(2):126-133.
Ehrland, W, “Susceptibility to Infection After Vaccination”, Br Med J, Mar 11, 1972, 1:683.
Bastin, R et al, “Repeated Cholera Vaccination. Immunological “Depressive” effect,” Ann Med Interne (Paris), Jun-July 1974, 125(6-7):513-518.
Kumar, L et al, “Cell-Mediated Immuno-deficiency with Normal Immunoglobulins (Nezelof’s Syndrome) with Progressive Vaccinia”, Indian Pediatr, Jan 1977, 14(1):69-72.
Stickl, H, “Iatrogenic Immunosuppression as a Result of Vaccination”, Fortschr Med, Mar 5, 1981, 99(9):289-292.
Daniliuk, O S et al, “Immunodepressive action Vaccinia Virus”, Biull Eksp Biol Med, Jul 1982, 94(7):73-74.
Castan, P et al, “Coma Revealing an acute Leukosis in a child, 15 days after an Oral Anti-poliomyelitis Vaccination,” Acta Neurol Bekg, May 1965, 65:349-367.
Pletsityl, DF, et al, “The Effect of the Vaccinal Process on the Non-specific Phagocytic Activity of Peripheral Blood Leukocytes”, Biull Eksp Biol Med, Mar 1973, 75(3):76-79.
Green, MS, et al , “Depression of Immune Response to an Inactivated Hepatitis A Vaccine Administered Concomitantly with Immune Globulin”, J Infect Dis, 1993 Sep; 168(3):740-743.
Beckenhauer, W H, et al, “Immunosuppression with Combined Vaccines”, J AM Vet Med Assoc, Aug 15, 1983, 183(4):389-390.
Green, MS, et al , “Depression of Immune Response to an Inactivated Hepatitis A Vaccine Administered Concomitantly with Immune Globulin”, J Infect Dis, 1993 Sep; 168(3):740-743.
Kotwal, G j et al, “Inhibition of the Complement Cascade by the Major Secretory Protein of Vaccinia Virus”, Science, Nov 9, 1990, 250(4982):827-830.
Strauss, J et al, “Loss of Maternal Measles Antibodies Acquired By Vaccination Against Measles,” Cesk epidemiol Mikrobiol Immunol, May 1991, 40(3):137-143.
Fattom, A, Cho, Y.H, Chu, C.Y, Fuller, S, Fries, L, Naso, R, “Vaccines May Cause Immune Suppression ….”, Vaccine, Jan 1999;17(2):126-133.
Blumberg DA, “Leukocyte responses to diphtheria-tetanus-pertussis and diphtheria-tetanus immunization”, Pediatr Infect Dis J 1991 Mar; 10(3):247-248.
Vaccinations and AIDS Citations:
Scheier, R, Hepatitis vaccine: the Danger of AIDS Transmission, Z Hautkr, 1984 Apr 15; 59(8):502-506.
Macek, C, “AIDS Transmission: What about the Hepatitis B Vaccine?”, JAMA, 1983 Feb 11; 249(6):685-686.
NA, “The Risk of AIDS after Hepatitis Vaccination,” JAMA, 1985 May 24-31; 253(20):2960-2961.
Taubman, L B, et al, “The Question of Possible Relationship Between Hepatitis B Vaccine and AIDS”, AM J Med, 1984 Apr; 76(4): A 59.
Kato, S et al, “Hepatitis B Vaccination and AIDS,” JAMA, 1985 Jul 5; 254(1):53.
Schwartz, AM, et al, “Hepatitis Vaccine and the Acquired Immunodeficiency Syndrome”, 1983, JAMA, Oct: 99(4):567-568.
Sacks, H S, et al, “Should the Risk of Acquired Immunodeficiency Syndrome deter Hepatitis B Vaccination?” A Decision Analysis.” JAMA, 1984 Dec 28; 252(24): 3375-3377.
Papaevangelou, G et al, “Risk of AIDS in Recipients of Hepatitis B Vaccine”, NEJM, 1985 Feb 7; 312(6):376-377.
Francis, DP, et al, “The Safety of the Hepatitis B Vaccine. Inactivation of the AIDS virus During Routine Manufacture”, JAMA, 1986 Aug 15; 256(7): 869-872.
Schultz, TF, “Origin of AIDS,” Lancet, Mar 7, 1992, 339(8797):867
Can vaccines cause food allergies?
JAMA 2001 Apr 4;285(13):1746-8 Detection of peanut allergens in breast milk of lactating women states, “Most individuals who react to peanuts do so on their first known exposure”……………..and concluded “Peanut protein is secreted into breast milk of lactating women following maternal dietary ingestion. Exposure to peanut protein during breastfeeding is a route of occult exposure that may result in sensitization of at-risk infants.” PMID 11277829
Women have been ingesting peanut protein while breastfeeding for decades. What has changed in the last 15 years to cause infants to develop life-threatening allergies to this legume? One change has been the vaccination schedule.
The Int Arch Allergy Immunol 1999 Jul; 119(3):205-11 Pertussis adjuvant prolongs intestinal hypersensitivity concludes: Our findings indicate nanogram quantities of PT (pertussis toxin), when administered with a food protein, result in long-term sensitization to the antigen, and altered intestinal neuroimmune function. These data suggest that exposure to bacterial pathogens may prolong the normally transient immune responsiveness to inert food antigens. PMID 10436392
Does this study explain why babies and toddlers react on their first exposure to the peanuts or other antigens? The babies may have been sensitized by the vaccines to the proteins through breast milk or formula ingested at the time of vaccination. This would also explain why children are anaphylactic to a variety of proteins, such as different tree nuts, peanuts, egg, legumes, milk, seeds, etc., depending on what proteins the mother ate at the time of pregnancy?
Is the introduction of the HiB vaccine connected to the increase in food analphyaxis in children?
Rates of anaphylaxis have increased dramatically since the introduction of the Hib vaccine.
Clin Exp Pharmacol Physiol 1979 Mar-Apr;6(2):139-49 Comparison of vaccination of mice and rats with Haemophilus influenzae and Bordetella pertussis as models of atopy, states “The Haemophilus influenzae vaccinated experimental animal provides a model that is possibly more related to human atopy than the Bordetella pertussis vaccinated animal.” PMID 311260
Ann Allergy 1979 Jan;42(1):36-40 states “To determine whether Haemophilus influenzae could be a factor in human atopy its effects were studied on the (para-)Sympathic Cyclic nucleotide-histamine axis in rats. Haemophilus influenzae vaccination induced changes in the cholinergic system compatible with higher cyclic GMP levels and enhanced histamine release. The authors suggest an involvement of the cholinergic system in Haemophilus influenzae vaccination effects. PMID 216288
Agents Actions 1984 Oct;15(3-4):211-5 entitled Bronchial hyper-reactivity to histamine induced by Haemophilus influenzae vaccination states “……This suggests a hyper-reactivity of the parasympathethic, cholinergic pathways as a result of H.influenzae vaccination.” PMID 6335351
Eur J. Pharmacol 1980 Apr 4;62(4):261-8 entitled The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release states “These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. Influenzae vaccination.” PMID 6154589
Can multiple vaccinations cause immune dysfunction related to asthma, allergies and anaphylaxis?
Read more about this here.
Taylor-Robinson, A.W. 1999. Multiple vaccination effects on atopy. Can vaccinations cause immune dysfunction resulting in allergies, asthma and anaphylaxis? Allergy 54: 398-399.
Rook GAW, Zumla A. Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? Lancet 1997;349:1831-1833.
Butler D. Admission on Gulf War vaccines spurs debate on medical records. Nature 1997;390:3-4.
Kemp T, Pearce N, Fitzharris Pet al. Is infant immunization a risk factor for childhood asthma or allergy? Epidemiology 1997;8:678-680.
Del Prete G. The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int Rev Immunol 1998;16:427-455.
Is there a link between the pertussis vaccines and asthma, allergies and anaphylaxis?
Pediatrics 1988 Jun (81) Supplement – Report on the Task Force on Pertussis and Pertussis Immunization – extract states, For more than 25 years, it has been known that pertussis vaccine is a reliable adjuvant for the production of experimental allergic encephalitis.
Bull Eur Physiopathol Respir 1987;23 Suppl 10:111s-113s A model for experimental asthma: provocation in guinea-pigs immunized with Bordetella pertussis states, ” Guinea-pigs were sensitized with killed Bordetella pertussis….. the presence of the immediate type of immune response was verified by passive cutaneous anaphylaxis….. B. pertussis not only alters adrenergic function but provocation in B. pertussis-sensitized guinea-pigs seems to be a good model for bronchial asthma. PMID 2889487
Pediatr Res 1987 Sep;22(3):262-7 Murine responses to immunization with pertussis toxin and bovine serum albumin: I. Mortality observed after bovine albumin challenge is due to an anaphylactic reaction……….the results of our experiments have established that the disease induced by coimmunizing mice with Ptx and BSA is due to an immediate type hypersensitivity. PMID 3309858
Infect Immun 1987 Apr.;55(4):1004-8 Anaphylaxis or so-called encephalopathy in mice sensitized to an antigen with the aid of pertussigen (pertussis toxin), states, Sensitization of mice with 1mg of bovine serum albumin (BSA) or chicken egg albumin (EA) ………….induced a high degree of anaphylactic sensitivity when the mice were challenged i.v. with 1 mg of antigen 14 days later. PMID 3557617
JAMA 1994 Aug 24-31;272(8):592-3 Pertussis vaccination and asthma: is there a link? A study of 450 children, 11% of the children who had received the pertussis vaccination suffered from asthma, as compared with only 2% of the children who had not been vaccinated. PMID 8057511
Allergy 1983 May;38(4):261-71 The non-specific enhancement of allergy. III. Precipitation of bronchial anaphylactic reactivity in primed rats by injection of alum or B. pertussis vaccine: relation of response capacity to IgE and IgG2a antibody levels. …..These results show that injection of alum or B. pertussis vaccine without antigen can precipitate/enhance anaphylactic response capacity and production of specific and non-specific IgE and IgG2a. PMID 6307077
Can vaccine adjuvants cause allergies and anaphylaxis?
J Allergy Clin Immunol 2001 Apr;107(4):693-702 Murine model of atopic dermatitis associated with food hypersensitivity states, “Female C3H/HeJ mice were sensitized orally to cow’s milk or peanut with a cholera toxin adjuvant and then subjected to low-grade allergen exposure………………..An eczematous eruption developed in approximately one third of mice after low-grade exposure to milk or peanut proteins……………….This eczematous eruption resembles AD (atopic dermatitis) in human subjects and should provide a useful model for studying immunopathogenic mechanisms of food hypersensitivity in AD.” PMID 11295660
Allergy 1980 Jan;35(1):65-71 Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs. Pattern of response in relation to immunization regimen….guinea-pigs sensitized with small amounts of antigen together with alum produced IgE and IgG1 antibodies. PMID 7369497
Allergy 1978 Jun:33(3):155-9 Aluminum phosphate but not calcium phosphate stimulates the specific IgE response in guinea pigs to tetanus toxoid. It is hypothesized that the regular application of aluminum compound-containing vaccines on the entire population could be one of the factors leading to the observed increase of allergic diseases. PMID 707792
Pediatric Allergy Immunol 1994 May;5(2):118-23 Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminum content of the vaccines. The role of aluminum for IgG and IgE responses to pertussis toxin (PT), as well as for side effects, was investigated in 49 children with known atopy status………………the addition of aluminum to the pertussis vaccine was, thus, associated with a stronger IgG antibody response, but tended also to induce a stronger IgE antibody response. The correlation between total IgE and PT-IgE, which was most prominent in children with atopy, indicates that the role of immunization for the development of allergy merits further studies. PMID 808719
Adv Drug Deliv Rev 1998 Jul 6;32(3):155-172 entitled Aluminum compounds as vaccine adjuvants stated, “Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-Cell responses. PMID 10837642
Annals of Asthma, Allergy and Immunology, Vol. 85, Number 1, July 2000 article T-cell subsets (Th1 versus Th2) includes Figure 7 on page 15 – “Factors responsible for the imbalance of the Th1/Th2 responses which is partly responsible for the increased prevalence of allergy in Western countries. Risk for atopy – Th2, increased exposure to some allergens and Th2-biasing vaccines (alum as adjuvant).” PMID 10923599
Vaccine 1992;10(10):714-20 Parameters affecting the immunogenicity of microencapsulated tetanus toxoid states “As expected, incomplete Freund’s adjuvant (IFA) proved to be a more potent adjuvant than peanut oil…………….” PMID 1523881
Can J Comp Med 1985 Apr;49(2):149-51 compared 6 different adjuvants in swine including four mineral oil compounds, one peanut oil compound and aluminum hydroxide. PMID 4016580
C R Acad Sci Hebd Seances Acad Sci D 1975 Apr 7;280(13):1629-32 states…….. a stable water in oil emulsion can be produced by using metabolizable peanut oil with arlacel. When mycobacteria are added, a potent emulsified oil adjuvant is obtained which increases the immune response to BSA and to influenza vaccine. PMID 811378
Are vaccines responsible for the epidemic of anaphylaxis in young children?
Read more here.
Van Odijk J. et al, Specific IgE antibodies to peanut in western Sweden – has the occurrence of peanut allergy increased without an increase in consumption? Allergy 2001 Jun;56(6):573-7
Ewan, PW, Clinical study of peanut and nut allergy in 62 consecutive patients: new features and associations. BMJ 1996 Apr 27;312(7038):1074-8. http://bmj.com/cgi/content/full/312/7038/1074
Vadas, P, et al, Detection of peanut allergens in breast milk of lactating women. JAMA 2001 Apr 4;285(13):1746-8.
Zimmerman B, et al. Highly atopic children: formation of IgE antibody to food protein, especially peanut. J Allergy Clin Immunol 1989 Apr;83(4):764-70 PMID 2708736
Study Acquits Peanuts in Allergic Reaction – Finds condition stems from abnormal immune response. Accessed April 6, 2006 http://www.healthcentral.com/news/
Turcanu V, et al. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J. Clin. Invest. 2003 Apr; 111:1065-72. PMID: 12671056 http://www.jci.org/cgi/content/full/111/7/950
Nicol M, et al. Haemophilus influenzae type b conjugate vaccine diluted tenfold in diphtheria-tetanus-whole cell pertussis vaccine: a randomized trial. Pediatr Infect Dis J 2002 Feb;21(2):138-41 PMID: 11840081
Pichichero, ME. New Combination Vaccines. Pediatr Clin North Am 2000 Apr;47(2):497-26 PMID: 10761511
Scheifele et al. Breastfeeding and antibody responses to routine vaccination in infants. Lancet. 1992 Dec 5;340(8832):1406.
Rennels MB et al, Diminution of the anti-polyribosylribitol phosphate response to a combined diphtheria-tetanus-acellular pertussis/Haemophils influenzae type b vaccine by concurrent inactivated poliovirus vaccination. Pediatr Infect Dis J 2000 May;19(5):417-23
Redhead K et al. Combination of DTP and Haemophilus influenzae type b conjugate vaccines can affect laboratory evaluation of potency and immunogenicity. Biologicals 1994 Dec;22(4);339-45 PMID 7779360
Primeau MN, Adkinson NF Jr, Hamilton RG. Natural rubber pharmaceutical vial closures release latex allergens that produce skin reactions. J Allergy Clin Immunol 2001 Jun;107(6):958-62 PMID: 11398071
Granoff DM, Munson RS Jr. Prospects for prevention of Haemophilus influenzae type b disease by immunization. J Infect Dis 1986 Mar;153(3):448-61 PMID: 3485160
Munson RS Jr, Granoff DM. Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b. Infect Immun. 1985 Sep;49(3):544-9. PMID: 2411657
Munson RS Jr, et al. Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates. J Clin Invest. 1983 Aug;72(2):677-84. PMID: 6603479
Pichichero ME, et al. Do pili play a role in pathogenicity of Haemophilus influenzae type B? Lancet. 1982 Oct 30;2(8305):960-2. PMID: 6127463
Hetherington SV, et al. Outer membrane protein binding sites of complement component 3 during opsonization of Haemophilus influenzae. Infect Immun. 1993 Dec;61(12):5157-63. PMID: 7693595
Coulton JW, Wan DT. The outer membrane of haemophilus influenzae type b: cell envelope associations of major proteins. Can J Microbiol. 1983 Feb;29(2):280-7. PMID: 6406024
Barenkamp SJ, Munson RS Jr, Granoff DM. Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles. J Infect Dis. 1981 May;143(5):668-76. PMID: 6972422
Iwamoto R, et al. An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor. J Biol Chem. 1991 Oct 25;266(30):20463-9. PMID: 1939101
Battistini A, et al. Inhibition of protein synthesis by diphtheria toxin induces a peculiar pattern of synthesized protein species. Exp Cell Res. 1988 May;176(1):174-9. PMID: 3371422
Kegel B, Bonifas U, Silberbach K, Kramer B, Weisser K. In vitro determination of specific toxicity in tetanus vaccines. Dev Biol (Basel). 2002;111:27-33. PMID: 12678222
Mayorga C, et al. Immediate allergy to tetanus toxoid vaccine: determination of immunoglobulin E and immunoglobulin G antibodies to allergenic proteins. Ann Allergy Asthma Immunol. 2003 Feb;90(2):238-43. PMID: 12602673
Roberts M, et al. A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins. Infect Immun. 1995 Jun;63(6):2100-8. PMID: 7768587
Mayorga C, et al. Immediate allergy to tetanus toxoid vaccine: determination of immunoglobulin E and immunoglobulin G antibodies to allergenic proteins. Ann Allergy Asthma Immunol. 2003 Feb;90(2):238-43. PMID: 12602673
De Gaspari EN. Production and characterization of new monoclonal antibody against Neisseria meningitidis: study of the cross-reactivity with different bacterial genera. Hybridoma 2000 Dec;19(6):445-53 PMID: 11152396
Pons L, et al. The 18 kDa peanut oleosin is a candidate allergen for IgE-mediated reactions to peanuts. Allergy. 2002;57 Suppl 72:88-93. PMID: 12144563
Kleber-Janke T, et al. Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol. 1999 Aug;119(4):265-74. PMID: 10474031
de Jong EC, et al. Identification and partial characterization of multiple major allergens in peanut proteins. Clin Exp Allergy. 1998 Jun;28(6):743-51. PMID: 9677140
Lewis SA, et al. The promiscuity of immunoglobulin E binding to peanut allergens, as determined by Western blotting, correlates with the severity of clinical symptoms. Clin Exp Allergy. 2005 Jun;35(6):767-73. PMID: 15969668
Pasini G, et al. IgE binding to almond proteins in two CAP-FEIA-negative patients with allergic symptoms to almond as compared to three CAP-FEIA-false-positive subjects. Allergy. 2000 Oct;55(10):955-8. PMID: 11030377
Lee SH, et al. A 50 kDa maize gamma-zein has marked cross-reactivity with the almond major protein. J Agric Food Chem. 2005 Oct 5;53(20):7965-70. PMID: 16190657
Malkiel S, Hargis BJ. The use of adjuvants in sensitization of the mouse. J Allergy. 1959 Sep-Oct;30:387-93.
Kind LS, Roesner L. Enhanced susceptibility of pertussis inoculated mice to pollen extract. Proc Soc Exp Biol Med. 1959 Apr;100(4):808-10.
Kind LS, Richards WW. IND LS. Local and systemic anaphylaxis in the pertussis-inoculated mouse. Nature. 1964 Apr 18;202:309-10.
Nelson MR et al, Anaphylaxis Complicating Routine Childhood Immunization: Hemophilus Influenza b Conjugated Vaccine. Pediatric Asthma, Allergy & Immunology Dec 2000,14, No. 4:315-321
Cooke et al, Allergy Induced by Immunization with Tetanus Toxoid. Journal of the American Medical Association. 1940 May;114(19):1854-58
Neill et al, Studies on Hypersensitiveness to Diphtheria Bacilli. Journal of Experimental Medicine 1929 Jan, 44:33
Patrizi et al, Sensitization to thimerosal in atopic children. Contact Dermatitis. 1999 Feb;40(2):94-7
Osawa J et al, A probable role for vaccines containing thimerosal in thimerosal hypersensitivity. Contact Dermatitis 1991 Mar;24(3):178-82
Martin-Munoz MF et al. Anaphylactic reaction to diphtheria-tetanus vaccine in a child: specific IgE/IgG determinations and cross-reactivity studies. Vaccine 2002 Sep 10;20(27-28):3409-12
Kumagai T et al, Gelatin-specific cellular immune responses persist for more than 3 years after priming with gelatin containing DTaP vaccine. Clin Exp Allergy 2002 Oct;32(10):1510-4
Sakaguchi M. et al, Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines. J Allergy Clin Immunol. 1996 Dec;98(6 Pt 1):1058-61.
Nakayama T, et al. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):321-5. PMID: 9949325
From the journal Allergy 1999, 54, 398-399, Multiple Vaccination effects on atopy, “An increase in the incidence of childhood atopic diseases may be expected as a result of concurrent vaccination strategies that induce a Th2-biased immune response. What should be discussed is whether the prize of a reduction of common infectious diseases through a policy of mass vaccination from birth is worth the price of a higher prevalence of atopy.” PMID 10371102
Journal of Manipulative and Physiological Therapeutics, Feb. 2000; 23(2):81-90, Effects of diphtheria-tetanus-pertussis or tetanus vaccination on allergies and allergy-related respiratory symptoms among children and adolescents in the United States, “The odds of having a history of asthma was twice as great among vaccinated subjects than among unvaccinated subjects. The odds of having any allergy-related respiratory symptom in the past 12 months was 63% greater among vaccinated subjects than unvaccinated subjects.” PMID 10714532
Thorax 1998 Nov;53(11):927-32 Early childhood infection and atopic disorder, stated “Interpretation of the prediction of atopic disorders by immunisation with whole cell pertussis vaccine and treatment with oral antibiotics needs to be very cautious because of the possibilities of confounding effects and reverse causation. However, plausible immune mechanisms are identifiable for the promotion of atopic disorders by both factors and further investigation of these association is warranted.” PMID 10193389
Epidemiology 1997 Nov;8(6):678-80 Is infant immunization a risk factor for childhood asthma or allergy? This study followed 1,265 children born in 1977. The 23 children who received no DPT and polio immunizations had no recorded asthma episodes or consultations for asthma or other allergic illness before age 10 years; in the immunized children, 23.1% had asthma episodes, 22.5% asthma consultations, and 30% consultations for other allergic illness. Similar differences were observed at ages 5 and 16 years. PMID 9345669
Arerugi 2000 Jul;49(7):585-92, The Effect of DPT and BCG vaccinations on atopic disorders findings include, “From these results we conclude that DPT vaccination has some effect in the promotion of atopic disorders…….” PMID 10944825
International Archives of Allergy and Immunology 121:1:2000, 2-9, Genetic and environmental factors contributing to the onset of allergic disorders. “The increasing prevalence of allergy in developed countries suggests that environmental factors acting either before or after birth also contribute to regulate the development of Th2 cells and/or their function. The reduction of infectious diseases in early life due to increasing vaccinations, antimicrobial treatments as well as changed lifestyle are certainly important in influencing the individual outcome in the Th response to ubiquitous allergens. PMID 10686503
Want to read more?
- Generation Rescue has several more peer-reviewed scientific papers on vaccinations here.
- Vaccination Risk Awareness Network discusses a lot of scientific research on vaccinations as well.
- What about the 14 studies that support the false assertion that vaccines do not cause autism? Read more about them here.
- Refer to Dr. Sherri Tenpenny’s Saying No to Vaccines book, which lists more than 350 scientific references documenting vaccine problems.
- Vaccine Information Coalition – More links to research about autism here.
- 60 lab studies confirm link between polio vaccine and cancer.
- Regarding Caroline’s compilation of 15 scientific papers about vaccinations, including abstracts here.
- More research here.